Description

Razuprotafib Sodium is a potent and selective small molecule inhibitor of the KRAS G12C oncoprotein. This compound is of significant interest for its role in targeted cancer therapy research, specifically in addressing difficult-to-treat mutations. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in oncology drug discovery and preclinical development.

Application

• Oncology Research & Drug Discovery: A key tool compound for studying KRAS G12C signaling pathways and tumor biology.
• Preclinical Development: Used in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and mechanism of action for potential therapeutics.
• Biochemical Assays: Serves as a reference standard in high-throughput screening (HTS) and enzyme inhibition assays targeting mutant KRAS.
• Combination Therapy Studies: Investigated for synergistic effects when used with other targeted agents or immunotherapies.
• Chemical Biology: Employed to probe protein-protein interactions and downstream effector pathways driven by oncogenic KRAS.

Basic Information

Product Name	Razuprotafib Sodium
CAS No.	1809275-69-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Razuprotafib Sodium Salt; LY3537982; (S)-2-(2-(5-Chloro-4-((2-isopropyl-4-methylpyridin-3-yl)amino)pyrimidin-2-yl)amino)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)propan-1-ol sodium salt; JNJ-74699157; ARS-3248; KRAS G12C Inhibitor LY3537982; ONO-7918
EINECS	Contact for details

Quality Control

Our Razuprotafib Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research use. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.