Description

1-Piperidinepropanenitrile, 3-[(6,7-Dihydro-5H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Methylamino]-4-Methyl-β-Oxo-, (3R,4R)-, 2-Hydroxy-1,2,3-Propanetricarboxylate (1:1) is a high-purity, non-racemic chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters as a sophisticated building block designed for the development of targeted therapeutics, offering precise stereochemical control. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors working on novel small-molecule drug candidates, particularly kinase inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of advanced active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Research: Key structural component in the discovery and development of potent and selective kinase inhibitors for oncology and other therapeutic areas.
• Preclinical & Process Chemistry: Used in route scouting, optimization, and scale-up activities from milligram to kilogram scale for clinical trial material production.
• Chemical Biology Probes: Employed in the construction of molecular probes for studying enzyme function and cellular signaling pathways.
• Asymmetric Synthesis: Utilized in reactions requiring high enantiomeric purity to impart desired pharmacological properties.

Basic Information

Product Name	1-Piperidinepropanenitrile, 3-[(6,7-Dihydro-5H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Methylamino]-4-Methyl-β-Oxo-, (3R,4R)-, 2-Hydroxy-1,2,3-Propanetricarboxylate (1:1)
CAS No.	1809002-40-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(3R,4R)-3-[(6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino]-4-methyl-β-oxo-1-piperidinepropanenitrile 2-hydroxy-1,2,3-propanetricarboxylate (1:1); (3R,4R)-3-(((6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)methyl)amino)-4-methyl-2-oxopiperidine-1-propanenitrile citrate salt; Citrate salt of a pyrrolopyrimidine-piperidine derivative; Advanced kinase inhibitor intermediate; Chiral piperidine nitrile citrate.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) with complete analytical data are provided to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.