Description

Methyl 6-((((2-Cyanoethoxy)(Diisopropylamino)Phosphanyl)-Oxy)Methyl) Nicotinate is a sophisticated phosphoramidite monomer, a critical building block in automated oligonucleotide synthesis. This compound matters for its high coupling efficiency and purity, which are essential for producing high-quality DNA and RNA sequences with minimal errors. It is primarily needed by biotechnology and pharmaceutical companies engaged in the research and development of therapeutic oligonucleotides, diagnostic probes, and synthetic genes.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite reagent for the automated synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense oligonucleotides, siRNA, and aptamers for drug development.
• Diagnostic Probe Synthesis: Creation of labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Research-Grade Oligo Production: For academic and industrial research requiring custom primers, linkers, and gene fragments.
• Synthetic Biology: Construction of artificial genes and genetic circuits.
• Next-Generation Sequencing (NGS): Synthesis of oligonucleotides used as adapters and primers in sequencing workflows.

Basic Information

Product Name	Methyl 6-((((2-Cyanoethoxy)(Diisopropylamino)Phosphanyl)-Oxy)Methyl) Nicotinate
CAS No.	1808096-82-3
Molecular Formula	C19H30N3O4P
Molecular Weight	395.44 g/mol
Synonyms	6-((((2-Cyanoethoxy)(diisopropylamino)phosphanyl)oxy)methyl)nicotinic acid methyl ester; Nicotinic acid, 6-((((2-cyanoethoxy)(diisopropylamino)phosphinyl)oxy)methyl)-, methyl ester; 6-(Hydroxymethyl)nicotinate phosphoramidite; 6-Methyl Nicotinate Phosphoramidite; DNA/RNA Synthesis Monomer; Phosphoramidite monomer for oligonucleotide synthesis
EINECS	Contact for details

Quality Control

Our Methyl 6-((((2-Cyanoethoxy)(Diisopropylamino)Phosphanyl)-Oxy)Methyl) Nicotinate is manufactured under strict quality systems to ensure it meets the exacting standards required for oligonucleotide synthesis. Every batch undergoes comprehensive analytical testing, including HPLC, 31P NMR, and 1H NMR, to confirm identity, purity, and stability. Certificates of Analysis (COA) with full traceability are provided for each lot, supporting applications in GMP-grade therapeutic manufacturing and critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid or solid
Identification (HPLC)	Conforms
Identification (31P NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.