Description

4-Chloro-2,3-Difluorobenzyl Alcohol CAS NO 1805647-55-5 is a high-purity fluorinated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine substituents, which enable precise molecular modifications to tune the properties of target compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro and chloro groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated to introduce specific functional groups into polymer chains, improving material properties like chemical resistance and thermal stability.
• Cross-Coupling Reactions: Utilized in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl structures.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel fluorinated compounds.

Basic Information

Product Name	4-Chloro-2,3-Difluorobenzyl Alcohol
CAS No.	1805647-55-5
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	(4-Chloro-2,3-difluorophenyl)methanol; 2,3-Difluoro-4-chlorobenzyl alcohol; 4-Chloro-2,3-difluorobenzenemethanol; 1-(Chloro)-2,3-difluoro-4-(hydroxymethyl)benzene; α-Hydroxy-4-chloro-2,3-difluorotoluene; 4-Chloro-α,2,3-trifluorobenzyl alcohol (incorrect but common search variant); Benzenemethanol, 4-chloro-2,3-difluoro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3-Difluorobenzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.