Description

Cdk4/6-In-2 CAS NO 1800506-48-2 is a potent and selective small-molecule inhibitor targeting the cyclin-dependent kinases 4 and 6 (CDK4/6), key regulators of the cell cycle. This compound is a critical research tool for investigating cell proliferation mechanisms, oncogenesis, and developing novel therapeutic strategies for cancers such as breast cancer. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology drug discovery and preclinical studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific roles and signaling pathways of CDK4 and CDK6 in cell cycle progression.
• Oncology Drug Discovery: Serves as a key pharmacological tool and reference standard in high-throughput screening and lead optimization for developing novel anti-cancer therapeutics.
• Mechanistic Studies: Enables detailed investigation into cell cycle checkpoints, senescence, and the mechanisms of resistance to CDK4/6 inhibition in various cancer cell lines.
• Preclinical Development: Utilized in in vitro and in vivo models to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of potential CDK4/6-targeting drug candidates.

Basic Information

Item	Detail
Product Name	Cdk4/6-In-2
CAS No.	1800506-48-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CDK4/6-IN-2; Cdk4/6 Inhibitor 2; 1800506-48-2; Cyclin-Dependent Kinase 4/6 Inhibitor 2; CDK4/6 Inhibitor; CDK4/6i-2
EINECS	Contact for details

Quality Control

Our Cdk4/6-In-2 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC purity and identity confirmation (NMR, MS). Certificates of Analysis (COA) are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.