Description

Tyk2-In-5 CAS NO 1797432-62-2 is a potent and selective small molecule inhibitor targeting the Tyrosine Kinase 2 (TYK2) enzyme, a key component of the JAK-STAT signaling pathway. This compound is crucial for advancing research into autoimmune diseases, inflammatory disorders, and oncology by providing a precise tool for modulating specific cytokine signaling. Pharmaceutical researchers, biotechnology companies, and academic institutions engaged in drug discovery and preclinical studies are the primary users of this high-purity biochemical.

Application

• Drug Discovery & Preclinical Research: Serves as a critical pharmacological tool for validating TYK2 as a therapeutic target in various disease models.
• Autoimmune Disease Studies: Used to investigate the role of TYK2 in conditions such as psoriasis, lupus, and inflammatory bowel disease (IBD).
• Inflammation Research: Applied in cellular and animal models to dissect cytokine signaling pathways involved in chronic inflammation.
• Oncology Research: Explored for its potential role in cancer biology where JAK-STAT signaling is dysregulated.
• Biochemical Assay Development: Employed as a standard or control compound in high-throughput screening (HTS) and enzyme inhibition assays.
• Structure-Activity Relationship (SAR) Studies: Provides a core scaffold for medicinal chemistry efforts to develop novel TYK2 inhibitors with improved properties.

Basic Information

Product Name	Tyk2-In-5
CAS No.	1797432-62-2
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	Tyk2-In-5; TYK2-IN-5; TYK2 Inhibitor 5; 2-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-6-[(1R)-1-hydroxyethyl]-N-[4-(4-methylpiperazin-1-yl)phenyl]pyridine-3-carboxamide; (R)-2-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-6-(1-hydroxyethyl)-N-(4-(4-methylpiperazin-1-yl)phenyl)nicotinamide
EINECS	Contact for details

Quality Control

Every batch of Tyk2-In-5 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and potency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for pharmaceutical research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.