Description

Crenolanib Trifluoroacetic Acid Salt is a high-purity, small molecule pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is a potent and selective inhibitor of FMS-like tyrosine kinase 3 (FLT3) and platelet-derived growth factor receptor (PDGFR), making it a critical component in advanced oncology research and development. It is essential for pharmaceutical manufacturers, research institutions, and CROs/CMOs engaged in the synthesis of targeted cancer therapeutics, particularly for acute myeloid leukemia (AML).

Application

• Pharmaceutical API Synthesis: Primary use as the active pharmaceutical ingredient in the formulation of targeted cancer drugs.
• Oncology Research & Development: A key reference standard and building block in preclinical and clinical studies for FLT3 and PDGFR-driven cancers.
• Process Chemistry & Scale-Up: Used in process development and optimization for the commercial manufacturing of Crenolanib-based therapies.
• Biochemical Assay Development: Serves as a potent inhibitor in cellular and enzymatic assays to study kinase signaling pathways.
• GMP Manufacturing: Supplied under controlled conditions for use in Good Manufacturing Practice (GMP) compliant drug production.
• Academic Research: Utilized in university and institutional labs for fundamental research into tyrosine kinase inhibitors and their mechanisms of action.

Basic Information

Item	Details
Product Name	Crenolanib Trifluoroacetic Acid Salt
CAS No.	1797008-57-1
Molecular Formula	C₂₆H₂₈F₃N₅O₃ • C₂HF₃O₂
Molecular Weight	Contact for details
Synonyms	Crenolanib TFA Salt; Crenolanib Trifluoroacetate; CP-868596 TFA Salt; 6-[2,6-Dichloro-4-[[3-(methylamino)propoxy]anilino]-N-[(1S)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidine-4-carboxamide Trifluoroacetic Acid Salt; FLT3/PDGFR Inhibitor Crenolanib TFA; Benzamide, 6-[2,6-dichloro-4-[[3-(methylamino)propoxy]phenyl]amino]-N-[(1S)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidine-4-carboxamide, 2,2,2-trifluoroacetate (1:1)
EINECS	Contact for details

Quality Control

Our Crenolanib Trifluoroacetic Acid Salt is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material suitable for research through to GMP-grade applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	<20 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.