Description

1-((2S,5R)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)-2-Methylpiperidin-1-Yl)Prop-2-En-1-One is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry critical for targeted drug development. This compound matters as a key building block in the synthesis of novel kinase inhibitors and other small molecule therapeutics, enabling precise biological activity. It is primarily needed by research institutions, pharmaceutical R&D departments, and CDMOs (Contract Development and Manufacturing Organizations) focused on oncology, immunology, and other life science applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted therapeutic agents, particularly kinase inhibitors.
• Oncology Drug Discovery: Used in research and development of novel anti-cancer compounds due to its specific molecular scaffold.
• Biochemical Research: Serves as a tool compound or reference standard in enzymatic assays and structure-activity relationship (SAR) studies.
• Preclinical Development: Employed in the scale-up synthesis for producing batches required for pharmacological and toxicological evaluation.
• Process Chemistry: Utilized by process chemists to develop and optimize robust, scalable synthetic routes for Active Pharmaceutical Ingredient (API) manufacturing.
• Academic Research: Used in university and institutional labs for medicinal chemistry projects exploring new therapeutic modalities.

Basic Information

Product Name	1-((2S,5R)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)-2-Methylpiperidin-1-Yl)Prop-2-En-1-One
CAS No.	1792180-81-4
Molecular Formula	C15H19N5O
Molecular Weight	285.35 g/mol
Synonyms	(2S,5R)-1-Acryloyl-2-methyl-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine; 1-[(2S,5R)-5-[(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino]-2-methyl-1-piperidinyl]-2-propen-1-one; (2S,5R)-N-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2-methyl-5-(prop-2-enoyl)piperidin-1-amine; Kinase Inhibitor Intermediate 1792180-81-4; Acryloyl-piperidine-pyrrolopyrimidine derivative
EINECS	Contact for details

Quality Control

Our 1-((2S,5R)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)-2-Methylpiperidin-1-Yl)Prop-2-En-1-One is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and comprehensive impurity profiling, to ensure compliance with research and development grade standards. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.