Description

1-((2R,5S)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)-2-Methylpiperidin-1-Yl)Prop-2-En-1-One is a high-purity, advanced pharmaceutical intermediate designed for targeted therapeutic development. This compound matters for its role as a key building block in the synthesis of novel kinase inhibitors and other small-molecule drugs, offering researchers precise control over molecular structure and activity. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and contract research organizations (CROs) engaged in oncology, immunology, and other precision medicine applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Research: Serves as a core scaffold for developing potent and selective kinase inhibitors targeting various disease pathways.
• Medicinal Chemistry & Lead Optimization: Used by research chemists to explore structure-activity relationships (SAR) and optimize drug candidate properties.
• Preclinical Development: Supports the production of compounds for in vitro and in vivo pharmacological and toxicological studies.
• Bioconjugation & Probe Development: The prop-2-en-1-one (acrylamide) moiety can be utilized for creating covalent inhibitors or diagnostic probes.
• Contract Manufacturing: Supplied to CDMOs for the cGMP-compliant production of clinical trial materials.

Basic Information

Product Name	1-((2R,5S)-5-((7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)-2-Methylpiperidin-1-Yl)Prop-2-En-1-One
CAS No.	1792180-79-0
Molecular Formula	C15H19N5O
Molecular Weight	285.35 g/mol
Synonyms	(2R,5S)-1-Acryloyl-2-methyl-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine; (R,S)-Enantiomer of a kinase inhibitor intermediate; 1-[(2R,5S)-5-[(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino]-2-methyl-1-piperidinyl]-2-propen-1-one; 2-Propen-1-one, 1-[(2R,5S)-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-2-methyl-1-piperidinyl]-; Acrylamide-piperidine-pyrrolopyrimidine conjugate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a quality management system that supports development under cGMP guidelines for pre-clinical and clinical stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.