Description

2-(2-Bromophenyl)-2,2-Difluoro-Ethanol is a high-value fluorinated organic building block characterized by a brominated phenyl ring and a difluoroethanol functional group. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, particularly where the introduction of fluorine atoms is required to modulate biological activity, metabolic stability, and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in CNS, oncology, and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where fluorine substitution enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated monomers and polymers for specialty materials with unique surface properties and chemical resistance.
• Chemical Biology Probes: Useful in designing molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-(2-Bromophenyl)-2,2-Difluoro-Ethanol
CAS No.	1785278-61-6
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	2-(2-Bromophenyl)-2,2-difluoroethan-1-ol; α,α-Difluoro-2-bromobenzeneethanol; 1-(2-Bromophenyl)-2,2-difluoroethanol; 2-Bromo-α,α-difluorobenzeneethanol; (2-Bromophenyl)difluoromethyl carbinol; 2,2-Difluoro-2-(2-bromophenyl)ethanol
EINECS	Contact for details

Quality Control

Our 2-(2-Bromophenyl)-2,2-Difluoro-Ethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent identity. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications in GMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.