Description

4-(1,1-Difluoroethyl)-α-Methyl- Benzenemethanol is a specialized fluorinated aromatic alcohol building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which incorporates both a difluoroethyl group and a benzylic alcohol, making it a valuable precursor for creating novel materials and active pharmaceutical ingredients (APIs) with tailored properties. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine atoms into complex molecules to modulate their bioactivity, metabolic stability, and physical characteristics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas requiring fluorinated motifs for enhanced potency and pharmacokinetics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the difluoroethyl group can improve biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Organofluorine Chemistry Research: An important reagent for academic and industrial research focused on developing new fluorination methodologies and studying structure-activity relationships.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, complex fluorinated intermediates.

Basic Information

Product Name	4-(1,1-Difluoroethyl)-α-Methyl- Benzenemethanol
CAS No.	1780591-16-3
Molecular Formula	C11H14F2O
Molecular Weight	200.23 g/mol
Synonyms	α-Methyl-4-(1,1-difluoroethyl)benzenemethanol; 1-[4-(1,1-Difluoroethyl)phenyl]ethanol; (4-(1,1-Difluoroethyl)phenyl)methylcarbinol; 4-(1,1-Difluoroethyl)-α-methylbenzyl alcohol; 1-(4-(1,1-Difluoroethyl)phenyl)ethan-1-ol; Benzenemethanol, 4-(1,1-difluoroethyl)-α-methyl-; p-(1,1-Difluoroethyl)-α-methylbenzyl alcohol
EINECS	Contact for details

Quality Control

Our 4-(1,1-Difluoroethyl)-α-Methyl- Benzenemethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98.0 - 99.5%)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.