Description

Cyclobutanecarboxylic Acid, 3-(Trifluoromethoxy)-,trans- is a high-purity, fluorinated organic building block of significant interest in advanced chemical synthesis. This compound is valued for its unique structural motif, combining a strained cyclobutane ring with a trifluoromethoxy substituent, which can impart desirable properties like metabolic stability and lipophilicity to target molecules. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for designing specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with tailored electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: A critical building block for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-(Trifluoromethoxy)-,trans-
CAS No.	1773508-19-2
Molecular Formula	C7H7F3O3
Molecular Weight	196.12 g/mol
Synonyms	trans-3-(Trifluoromethoxy)cyclobutanecarboxylic Acid; (1r,3r)-3-(Trifluoromethoxy)cyclobutanecarboxylic Acid; rel-(1R,3R)-3-(Trifluoromethoxy)cyclobutanecarboxylic Acid; 3-(Trifluoromethoxy)cyclobutanecarboxylic Acid, trans-; (1R,3R)-3-(Trifluoromethoxyl)cyclobutanecarboxylic Acid; 3-(Trifluoromethoxy)cyclobutane-1-carboxylic Acid; 3-Trifluoromethoxycyclobutanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-(Trifluoromethoxy)-,trans- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (trans isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.