Description

(2S)-n-[4-[[3-Cyano-1-[(3,5-Dimethyl-4-Isoxazolyl)Methyl]-1H-Indol-5-Yl]Oxy]Phenyl]-2-Pyrrolidinecarboxamide is a high-purity, non-racemic chiral compound designed for advanced research and development. This molecule is of significant interest as a key synthetic intermediate or potential pharmacologically active ingredient in the discovery of new therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly in oncology and CNS research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Biochemical Tool Compound: Acts as a selective probe or inhibitor in enzymatic and receptor-binding assays to study specific biological pathways.
• Preclinical Development: Supplied for use in early-stage in vitro and in vivo pharmacological evaluation and toxicology studies.
• Reference Standard: Provides a high-purity chiral standard for analytical method development, validation, and quality control in API manufacturing.
• Custom Synthesis Starting Material: Used for the preparation of more complex, targeted molecular libraries for high-throughput screening.

Basic Information

Product Name	(2S)-n-[4-[[3-Cyano-1-[(3,5-Dimethyl-4-Isoxazolyl)Methyl]-1H-Indol-5-Yl]Oxy]Phenyl]-2-Pyrrolidinecarboxamide
CAS No.	1704741-11-6
Molecular Formula	C27H25N5O3
Molecular Weight	467.52 g/mol
Synonyms	(2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide; UNII-6J2J8Z6K8F; 6J2J8Z6K8F; (S)-N-(4-((3-Cyano-1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-indol-5-yl)oxy)phenyl)pyrrolidine-2-carboxamide; (2S)-N-[4-({3-Cyano-1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-1H-indol-5-yl}oxy)phenyl]pyrrolidine-2-carboxamide; Apatinib Impurity 66; (S)-Apatinib Impurity 66
EINECS	Contact for details

Quality Control

Our (2S)-n-[4-[[3-Cyano-1-[(3,5-Dimethyl-4-Isoxazolyl)Methyl]-1H-Indol-5-Yl]Oxy]Phenyl]-2-Pyrrolidinecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.