Description

Ipi-549 is a potent and selective small molecule inhibitor of the phosphoinositide-3-kinase gamma (PI3Kγ) isoform, a key regulator of immune cell function. This compound is of significant interest for its potential to modulate the tumor microenvironment and enhance anti-tumor immunity. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and immunology for preclinical and clinical-stage drug discovery programs.

Application

• Oncology Research: Investigation as an immuno-oncology agent to overcome immunosuppression in solid tumors.
• Immunology Studies: Tool compound for studying the role of PI3Kγ signaling in macrophage polarization and myeloid cell function.
• Drug Discovery: Key intermediate or reference standard in the development of novel PI3Kγ-targeted therapeutics.
• Preclinical Development: Used in in vitro and in vivo models to assess efficacy, pharmacokinetics, and mechanism of action.
• Combination Therapy Research: Exploration of synergistic effects with checkpoint inhibitors, chemotherapy, or other targeted agents.

Basic Information

Product Name	Ipi-549
CAS No.	1693758-51-8
Molecular Formula	C₂₉H₃₀N₆O₃
Molecular Weight	510.59 g/mol
Synonyms	IPI-549; Eganelisib; (S)-1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea; PI3K-gamma inhibitor IPI-549; PU-AD; GSK-226; GNE-293
EINECS	Contact for details

Quality Control

Our Ipi-549 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.