Description

(R)-Zanubrutinib CAS NO 1691249-44-1 is the R-enantiomer of Zanubrutinib, a potent and highly selective small molecule inhibitor of Bruton's tyrosine kinase (BTK). This compound is a critical intermediate and reference standard in the research and development of targeted oncology therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers focused on precision medicine and enantiomerically pure drug substances.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in the production of the active pharmaceutical ingredient (API).
• Preclinical & Clinical Research: Serves as a key intermediate and biological probe in pharmacological studies to investigate the specific activity of the (R)-enantiomer.
• Process Chemistry & Development: Employed in route scouting, optimization, and scale-up studies for the synthesis of enantiomerically pure BTK inhibitors.
• Impurity Profiling: Acts as a critical chiral impurity standard to monitor and control the stereochemical purity of Zanubrutinib bulk drug substance.
• Academic Research: Utilized in biochemical and structural biology research to study BTK signaling pathways and inhibitor binding mechanisms.

Basic Information

Product Name	(R)-Zanubrutinib
CAS No.	1691249-44-1
Molecular Formula	C27H29N5O3
Molecular Weight	471.55 g/mol
Synonyms	(R)-Zanubrutinib; (R)-BGB-3111; (R)-2-((6-Acrylamido-4-(3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyridin-2-yl)amino)-N-methylpropionamide; (R)-Brukinsa Enantiomer; (R)-BTK Inhibitor BGB-3111; (R)-Enantiomer of Zanubrutinib
EINECS	Contact for details

Quality Control

Our (R)-Zanubrutinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and LC-MS for identity and purity verification. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the stringent requirements of pharmaceutical R&D and reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.