Description

(E)-Sunitinib CAS NO 1691223-83-2 is a specific stereoisomer of the multi-targeted receptor tyrosine kinase inhibitor Sunitinib, known for its high purity and defined chemical structure. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for oncology applications. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries who require precise chemical entities for drug synthesis, analytical method development, and biological activity studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical testing, method validation, and quality control of Sunitinib-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthetic pathway for the production of the anticancer drug Sunitinib malate.
• Biochemical Research: Employed in in vitro studies to investigate the structure-activity relationship (SAR) of tyrosine kinase inhibitors and their stereospecific effects.
• Preclinical Development: Utilized in the development and scaling of synthetic processes for novel kinase inhibitor candidates.
• Metabolite Studies: Acts as a precursor or analog for the synthesis and identification of Sunitinib metabolites in pharmacokinetic research.

Basic Information

Product Name	(E)-Sunitinib
CAS No.	1691223-83-2
Molecular Formula	C₂₂H₂₇FN₄O₂
Molecular Weight	398.47 g/mol
Synonyms	(E)-Sunitinib; Sunitinib (E)-isomer; (E)-N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; SU11248 (E)-isomer; (E)-5-Fluoro-3-[2,4-dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]-2-oxo-1H-indole-3-carboxylic acid (2-diethylaminoethyl)amide; (E)-Sunitinib Base
EINECS	Contact for details

Quality Control

Our (E)-Sunitinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed results to ensure compliance with research and development standards. Specifications can be tailored to meet the requirements of cGMP (current Good Manufacturing Practice) for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange solid powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Assay	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.