Description

2'-Deoxy-3'-(4-(1,1-Dimethylethyl)Phenoxy]Acetyl- n-[[4-(1,1-Dimethylethyl)Phenoxy]Acetyl]Guanosine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical research and development. This compound matters for its role as a sophisticated intermediate in the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily needed by R&D laboratories, pharmaceutical manufacturers, and CROs (Contract Research Organizations) focused on nucleotide-based therapies and prodrug development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleotide analog prodrugs.
• Antiviral Drug Research: Used in the development of potential therapeutics targeting viral polymerases.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents designed to interfere with DNA synthesis in cancer cells.
• ProTide Technology: A key component in the synthesis of phosphoramidate prodrugs, a prominent technology platform for improving nucleotide drug delivery and efficacy.
• Biochemical Research: Utilized in studies investigating nucleoside metabolism, enzyme inhibition, and mechanism of action.
• Pre-clinical Development: Supplies material for pharmacokinetic, pharmacodynamic, and toxicology studies of new chemical entities.

Basic Information

Product Name	2'-Deoxy-3'-(4-(1,1-Dimethylethyl)Phenoxy]Acetyl- n-[[4-(1,1-Dimethylethyl)Phenoxy]Acetyl]Guanosine
CAS No.	1689501-53-8
Molecular Formula	C31H37N5O8
Molecular Weight	607.66 g/mol
Synonyms	3'-O-[(4-tert-Butylphenoxy)acetyl]-2'-deoxy-N-[(4-tert-butylphenoxy)acetyl]guanosine; 2'-Deoxy-3'-O-[2-(4-tert-butylphenoxy)acetyl]-N-[2-(4-tert-butylphenoxy)acetyl]guanosine; 2'-Deoxy-3'-(4-tert-butylphenoxy)acetyl-N-[(4-tert-butylphenoxy)acetyl]guanosine; tert-Butylphenoxy Acetyl Modified Guanosine; Nucleoside ProTide Intermediate; Guanosine, 2'-deoxy-3'-O-[2-(4-(1,1-dimethylethyl)phenoxy)acetyl]-N-[2-(4-(1,1-dimethylethyl)phenoxy)acetyl]-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-3'-(4-(1,1-Dimethylethyl)Phenoxy]Acetyl- n-[[4-(1,1-Dimethylethyl)Phenoxy]Acetyl]Guanosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.