Description

Venadaparib is a potent and selective small-molecule inhibitor of poly(ADP-ribose) polymerase (PARP) enzymes, a key target class in oncology research. Its primary value lies in its application as a high-purity reference standard and active pharmaceutical ingredient (API) for the development of novel cancer therapeutics, particularly for tumors with homologous recombination deficiencies. This compound is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on targeted cancer therapy, drug discovery, and preclinical studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in API and finished drug product manufacturing.
• Oncology Drug Discovery & Development: Serves as a key pharmacologically active compound for in vitro and in vivo studies targeting PARP1 and PARP2 enzymes.
• Biochemical Research: Employed in enzymatic assays and mechanistic studies to investigate the role of PARP inhibition in DNA damage repair pathways and synthetic lethality.
• Preclinical Candidate Evaluation: Utilized in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies to support Investigational New Drug (IND) applications.
• Combinatorial Therapy Research: Investigated in combination with other chemotherapeutic agents or radiation therapy to enhance anti-tumor efficacy.

Basic Information

Product Name	Venadaparib
CAS No.	1681017-83-3
Molecular Formula	C₂₀H₂₀FN₅O₂
Molecular Weight	381.40 g/mol
Synonyms	Venadaparib; AZD-5305; AZD5305; 2-[4-[(3S)-3-Piperidinyl]phenyl]-2H-indazole-7-carboxamide; (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; PARP Inhibitor AZD5305; AZD 5305
EINECS	Contact for details

Quality Control

Our Venadaparib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. We provide full traceability and support regulatory filings. A detailed Certificate of Analysis (COA) is available for every lot, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.