Description

2'--C-Methyl-2-Thiouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of novel oligonucleotides and therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral drugs, antisense oligonucleotides, and other RNA-targeted therapies. The product, identified by CAS NO 1678507-60-2, is supplied to meet the stringent purity requirements of modern life science applications.

Application

• Antiviral Drug Development: Serves as a critical intermediate in the synthesis of nucleoside analogs targeting viral polymerases.
• Antisense Oligonucleotide (ASO) Synthesis: Used as a modified monomer to enhance the stability and binding affinity of therapeutic oligonucleotides.
• RNA Therapeutics Research: Acts as a building block for siRNA, miRNA, and other RNA-based therapeutic platforms.
• Medicinal Chemistry & Lead Optimization: Employed in structure-activity relationship (SAR) studies to develop novel pharmacologically active compounds.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies related to RNA metabolism and function.
• Process Development & Scale-up: Supplied for route scouting and optimization in active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	2'--C-Methyl-2-Thiouridine
CAS No.	1678507-60-2
Molecular Formula	C11H16N2O5S
Molecular Weight	288.32 g/mol
Synonyms	2'-C-Methyl-2-thiouridine; 2-Thio-2'-C-methyluridine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-2-thioxo-1,2-dihydropyrimidin-4(3H)-one; 2'-Methyl-2-thiouridine; 2-Thiouridine, 2'-C-methyl-; 2'-C-Methyl-2-thio-uridine
EINECS	Contact for details

Quality Control

Our 2'--C-Methyl-2-Thiouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the product should be handled in a dry environment and the container kept sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.