Description

Pd-L1 Inhibitor 1 is a potent and selective small molecule inhibitor targeting the programmed death-ligand 1 (PD-L1) immune checkpoint pathway. This compound is crucial for advancing research and development in immuno-oncology, offering a tool to modulate the tumor microenvironment and potentially restore anti-tumor immune responses. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel cancer immunotherapies and combination treatment strategies.

Application

• Immuno-oncology Research: A key reagent for in vitro and in vivo studies investigating the PD-1/PD-L1 signaling axis and its role in cancer immune evasion.
• Drug Discovery & Development: Used as a reference standard, pharmacodynamic marker, or lead compound in the screening and optimization of next-generation immune checkpoint inhibitors.
• Mechanistic Biology Studies: Enables the exploration of PD-L1 function in various cell types and disease models beyond oncology, such as autoimmune or infectious diseases.
• Preclinical Evaluation: Supports efficacy and safety testing in animal models to understand pharmacokinetics, pharmacodynamics, and potential therapeutic windows for immunotherapy candidates.
• Biomarker Research: Assists in studies correlating PD-L1 expression or pathway inhibition with treatment response, aiding in the development of companion diagnostics.
• Combination Therapy Development: Used to study synergistic effects when combined with other therapeutic modalities like chemotherapy, radiotherapy, or other immunomodulators.

Basic Information

Product Name	Pd-L1 Inhibitor 1
CAS No.	1675203-84-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BMS-8; PD-L1 inhibitor BMS-8; BMS-8, PD-L1 inhibitor; (2S,4R)-1-((S)-2-(1H-indol-3-yl)-1-(4-(5-methoxy-7-methyl-1H-indol-4-yl)piperazin-1-yl)ethyl)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide; Programmed death-ligand 1 inhibitor 1; PD-L1 Inhibitor (BMS-8); BMS 8
EINECS	Contact for details

Quality Control

Our Pd-L1 Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducibility and traceability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.