Description

(S)-3-((7-((Difluoromethyl)Sulfonyl)-2,2-Difluoro-1-Hydroxy-2,3-Dihydro-1H-Inden-4-Yl)Oxy)-5-Fluorobenzonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multi-fluorinated indane structure. This compound is critical for enabling the synthesis of next-generation active pharmaceutical ingredients (APIs) with enhanced metabolic stability and target selectivity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and other specialized disease areas.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex, fluorinated drug candidates, leveraging its unique stereochemistry and functional groups.
• API Development: Integral to research and process development for new Active Pharmaceutical Ingredients (APIs), especially those targeting kinase inhibition or other specific biological pathways.
• Preclinical & Clinical Research: Used in the preparation of compounds for biological screening, pharmacokinetic studies, and toxicology assessments during drug discovery.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of novel therapeutic molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and development services.
• Academic Research: Utilized in university and institutional labs for methodological studies in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	(S)-3-((7-((Difluoromethyl)Sulfonyl)-2,2-Difluoro-1-Hydroxy-2,3-Dihydro-1H-Inden-4-Yl)Oxy)-5-Fluorobenzonitrile
CAS No.	1672662-14-4
Molecular Formula	C18H10F5NO4S
Molecular Weight	431.33 g/mol
Synonyms	(S)-5-Fluoro-3-((7-((difluoromethyl)sulfonyl)-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile; 5-Fluoro-3-[[7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydroinden-4-yl]oxy]benzonitrile; (S)-enantiomer of the indane sulfone derivative; CAS 1672662-14-4; Advanced Fluorinated Indane Intermediate; Chiral Fluorinated Sulfone Building Block
EINECS	Contact for details

Quality Control

Our production of (S)-3-((7-((Difluoromethyl)Sulfonyl)-2,2-Difluoro-1-Hydroxy-2,3-Dihydro-1H-Inden-4-Yl)Oxy)-5-Fluorobenzonitrile adheres to stringent quality systems suitable for pharmaceutical development. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results for chiral purity, chemical purity (HPLC), and residual solvents. We support development under GMP-like conditions where required and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; ensure the storage area is separate from such materials. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.