Description

2'-Deoxy-2'-Fluoroisocytidine is a fluorinated nucleoside analog of significant interest in advanced pharmaceutical research and development. This modified cytidine derivative is a key building block in the synthesis of oligonucleotides, particularly for antisense and siRNA therapeutic applications where enhanced nuclease resistance and binding affinity are required. It is primarily utilized by biotechnology companies, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the production of novel antiviral agents, cancer therapeutics, and genetic medicines.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite monomer for constructing oligonucleotides designed to modulate gene expression.
• siRNA and miRNA Therapeutics: Used in the solid-phase synthesis of small interfering RNA (siRNA) strands to improve stability and pharmacokinetic profiles.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Employed as a tool compound in enzymology studies to investigate polymerase fidelity and nucleotide metabolism.
• Diagnostic Probe Development: Utilized in the design of labeled probes for genetic testing and molecular diagnostics.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting viral and cellular polymerases.

Basic Information

Product Name	2'-Deoxy-2'-Fluoroisocytidine
CAS No.	1668560-65-3
Molecular Formula	C9H12FN3O4
Molecular Weight	245.21 g/mol
Synonyms	2'-Fluoro-2'-deoxyisocytidine; 4-Amino-1-((2R,3R,5R)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 2'-F-dIsoC; 2'-FluoroisoC; 1-((2R,3R,5R)-3-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-aminopyrimidin-2(1H)-one; Iso-dC-F; 2'-Deoxy-2'-fluoroisocytidine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoroisocytidine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and GMP-grade applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-process controls and final release testing, including HPLC, NMR, and MS analysis, to meet the exacting standards of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.