Description

Adenosine,2'-Deoxy-3'-0〔(1,1-Dimethylethyl)Dimethylsilyl]-5-O CAS NO 1661829-85-1 is a protected nucleoside derivative, specifically a silyl-protected deoxyadenosine analog, which serves as a critical building block in organic synthesis. This compound is of paramount importance for the controlled synthesis of oligonucleotides and nucleotide analogs, where protecting groups are essential for regioselective reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and advanced biochemical research.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor in the solid-phase synthesis of DNA and modified oligonucleotides for research and therapeutic applications.
• Antiviral & Anticancer Prodrug Development: Used as an intermediate in the synthesis of nucleoside-based prodrugs targeting viral replication and cancer cell proliferation.
• Biochemical Research: Employed in studies of enzyme mechanisms, nucleic acid interactions, and as a tool compound in molecular biology.
• Labeled Nucleotide Production: Serves as a starting material for the synthesis of fluorescence-labeled or radio-labeled nucleotides used in sequencing and detection assays.
• Pharmaceutical Intermediates: A vital building block for creating complex active pharmaceutical ingredients (APIs) in the nucleotide analog class.

Basic Information

Product Name	Adenosine,2'-Deoxy-3'-0〔(1,1-Dimethylethyl)Dimethylsilyl]-5-O
CAS No.	1661829-85-1
Molecular Formula	C16H27N5O4Si
Molecular Weight	381.51 g/mol
Synonyms	2'-Deoxy-3'-O-(tert-Butyldimethylsilyl)adenosine; 3'-O-TBDMS-2'-deoxyadenosine; 2'-Deoxyadenosine, 3'-(tert-butyldimethylsilyl) ether; 3'-TBDMS-dA; N6-Benzoyl-2'-deoxy-3'-O-(tert-butyldimethylsilyl)adenosine (protected variant); 9-[(2R,5R)-5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]tetrahydro-2-furanyl]-9H-purin-6-amine; TBDMS-protected 2'-deoxyadenosine
EINECS	Contact for details

Quality Control

Our Adenosine,2'-Deoxy-3'-0〔(1,1-Dimethylethyl)Dimethylsilyl]-5-O is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.