Description

Tenalisib R Enantiomer is the single, optically pure R-enantiomer of the potent and selective PI3Kδ inhibitor, Tenalisib. This high-purity chiral building block is critical for pharmaceutical research and development, particularly in the study of structure-activity relationships and the development of targeted therapies. It is primarily utilized by medicinal chemists and researchers in the pharmaceutical and biotechnology industries for preclinical studies and as a reference standard.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug substance and product testing.
• Medicinal Chemistry Research: Serves as a key chiral intermediate or building block for the synthesis of novel PI3Kδ inhibitors and related compounds.
• Biological Activity Studies: Employed in in vitro and in vivo studies to investigate the specific pharmacological profile, efficacy, and toxicity of the R-enantiomer independently.
• Process Chemistry & Development: Acts as a benchmark for developing and optimizing asymmetric synthesis routes and chiral separation techniques (e.g., SFC, HPLC).
• Academic Research: Utilized in university and institutional labs for fundamental research in oncology, immunology, and kinase inhibitor mechanisms.

Basic Information

Product Name	Tenalisib R Enantiomer
CAS No.	1639417-54-1
Molecular Formula	C₂₃H₂₅N₅O₂
Molecular Weight	403.48 g/mol
Synonyms	(R)-Tenalisib; (R)-RP6530; (R)-6-Fluoro-3-(2-((R)-3-methylmorpholino)pyrimidin-5-yl)-1-((1R,4R)-4-(4-methylpiperazin-1-yl)cyclohexyl)indolin-2-one; (R)-6-Fluoro-3-[2-[(3R)-3-methylmorpholin-4-yl]pyrimidin-5-yl]-1-[(1R,4R)-4-(4-methylpiperazin-1-yl)cyclohexyl]indolin-2-one; RP6530 R-Enantiomer; PI3Kδ Inhibitor R-Enantiomer; Tenalisib (R form)
EINECS	Contact for details

Quality Control

Our Tenalisib R Enantiomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral HPLC assay, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.