Description

Gs5829,Alobresib is a potent and selective small molecule inhibitor targeting the bromodomain and extra-terminal (BET) family of proteins. This compound is critical for advanced research in oncology and epigenetics, offering a valuable tool for investigating gene regulation pathways linked to cancer proliferation and inflammation. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs (Contract Research Organizations) engaged in the discovery of novel therapeutic agents.

Application

• Oncology Research: Used as a key biochemical tool to study the role of BET proteins in various cancer models, including hematological malignancies and solid tumors.
• Epigenetics Studies: Essential for probing bromodomain function and understanding the mechanisms of transcriptional regulation in disease states.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in high-throughput screening and structure-activity relationship (SAR) studies for novel BET inhibitors.
• Inflammatory Disease Research: Applied in preclinical research to investigate the modulation of inflammatory gene expression pathways.
• Chemical Biology: Utilized in proteomics and target engagement studies to validate BET family proteins as therapeutic targets.
• Preclinical Pharmacology: Employed in in vitro and in vivo studies to assess pharmacokinetics, efficacy, and safety profiles of BET inhibition.

Basic Information

Product Name	Gs5829,Alobresib
CAS No.	1637771-14-2
Molecular Formula	C₂₃H₂₀ClN₅O₂
Molecular Weight	433.89 g/mol
Synonyms	GS-5829; Alobresib; GSK525762; I-BET-762; Molibresib; (R)-N-(4-Chlorophenyl)-2-((4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)-3-methylbutanamide; BET Inhibitor GSK525762; CPI-0610 analog
EINECS	Contact for details

Quality Control

Our Gs5829,Alobresib is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by comprehensive analytical data, including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.