Description

Povorcitinib is a potent and selective Janus kinase 1 (JAK1) inhibitor, a key compound in the development of novel immunomodulatory therapeutics. Its high selectivity profile makes it a critical active pharmaceutical ingredient (API) for targeted inflammatory and autoimmune disease research. This compound is essential for pharmaceutical R&D teams, contract research organizations (CROs), and API manufacturers focused on advancing next-generation treatments for conditions like alopecia areata, atopic dermatitis, and vitiligo.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the commercial manufacturing of finished dosage forms.
• Clinical Trial Material (CTM) Production: Sourcing of high-purity material for Phase I-III clinical studies.
• Preclinical Research & Development: Investigation of JAK1 inhibition pathways, efficacy, and safety profiles in disease models.
• Formulation Development: Used in the development of various drug delivery systems, including oral tablets and topical formulations.
• Reference Standard: Serves as an analytical standard for quality control and method validation in regulatory submissions.
• Process Chemistry & Scale-Up: Supporting the development and optimization of robust, cost-effective synthetic routes for commercial-scale production.

Basic Information

Product Name	Povorcitinib
CAS No.	1637677-22-5
Molecular Formula	C₂₀H₂₃N₇O₂
Molecular Weight	393.45 g/mol
Synonyms	INCB054707; PF-06651600; (S)-3-(4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; (S)-3-(4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile; JAK1 Inhibitor (INCB054707); Ritlecitinib Impurity; JAK1/TYK2 Inhibitor
EINECS	Contact for details

Quality Control

Our Povorcitinib is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines for pharmaceutical ingredients. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from advanced analytical techniques including HPLC, NMR, and MS. We support regulatory filings with full traceability and stability data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.