Description

2,3-Difluoro-4-(Phenylmethoxy)Benzyl Alcohol is a high-value fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, featuring both a benzyl alcohol and a benzyl-protected phenol, which provides versatile handles for further functionalization in the creation of complex molecules. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, where the introduction of fluorine atoms is a key strategy to modulate biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where fluorination enhances lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a key synthon for constructing fluorinated aromatic cores in advanced electronic materials, improving charge transport and thermal stability.
• Polymer Science: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing material properties like chemical resistance, weatherability, and lowering dielectric constant.
• Chemical Biology & Probe Development: Utilized as a scaffold for creating fluorescent tags, molecular probes, and PROTACs (Proteolysis-Targeting Chimeras) due to its derivatizable handles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram.

Basic Information

Product Name	2,3-Difluoro-4-(Phenylmethoxy)Benzyl Alcohol
CAS No.	1637386-43-6
Molecular Formula	C14H12F2O2
Molecular Weight	250.24 g/mol
Synonyms	(2,3-Difluoro-4-((phenylmethoxy)methyl)phenyl)methanol; 2,3-Difluoro-4-(benzyloxymethyl)benzyl alcohol; 4-(Benzyloxymethyl)-2,3-difluorobenzyl alcohol; α-(Benzyloxy)-2,3-difluoro-p-tolylmethanol; 2,3-Difluoro-4-[(phenylmethoxy)methyl]benzenemethanol; Benzyl 2,3-difluoro-4-(hydroxymethyl)benzyl ether
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-(Phenylmethoxy)Benzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.