Description

Esaxerenone is a potent, non-steroidal mineralocorticoid receptor antagonist (MRA) of significant pharmaceutical interest. Its primary value lies in its high selectivity and efficacy for treating conditions like hypertension and chronic kidney disease, offering a targeted therapeutic approach. This compound is essential for pharmaceutical R&D teams, API manufacturers, and clinical research organizations focused on developing next-generation cardiovascular and renal therapeutics.

Application

• Active Pharmaceutical Ingredient (API) in antihypertensive medications.
• Research and Development of novel treatments for chronic kidney disease (CKD).
• Clinical Trial Material for studying mineralocorticoid receptor blockade.
• Reference Standard for analytical method development and quality control in pharmaceutical labs.
• Preclinical Studies investigating cardiorenal protective mechanisms.
• Formulation Development for oral solid dosage forms such as tablets.

Basic Information

Product Name	Esaxerenone
CAS No.	1632006-28-0
Molecular Formula	C17H16N2O5S
Molecular Weight	360.39 g/mol
Synonyms	CS-3150; Minnebro® (Brand Name); (5R)-5-[(4RS)-4-Hydroxy-6-methyl-3,4-dihydro-2H-1-benzothiopyran-4-yl]-1-methyl-2-imidazolidinone; 4-(5R)-5-(4-Hydroxy-6-methyl-3,4-dihydro-2H-1-benzothiopyran-4-yl)-1-methyl-2-imidazolidinone; 4-(5R)-5-(4-Hydroxy-6-methyl-3,4-dihydro-2H-1-benzothiopyran-4-yl)-1-methylimidazolidin-2-one; 4-[(5R)-1-Methyl-5-(4-hydroxy-6-methyl-3,4-dihydro-2H-1-benzothiopyran-4-yl)-2-oxoimidazolidin-4-yl]benzonitrile (common mis-assignment corrected); Non-steroidal MRA
EINECS	Contact for details

Quality Control

Our Esaxerenone is manufactured under strict quality management systems, targeting standards suitable for pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, related substances analysis, and residual solvent screening. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.