Description

n-[4-[(6,7-Dimethoxy-4-Quinolinyl)Oxy]Phenyl]-N'-(4-Fluoro-3-Hydroxyphenyl)-1,1-Cyclopropanedicarboxamide is a high-purity, advanced pharmaceutical intermediate designed for critical synthesis pathways. Its molecular architecture makes it a valuable building block for research and development in targeted therapeutic areas. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing novel small-molecule drugs, particularly in oncology and other specialized fields.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Oncology Research: Used in the R&D of targeted cancer therapies due to its specific quinoline-based structure.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and optimizing potent kinase inhibitors.
• Biochemical Research: Employed in biochemical assays and as a tool compound for studying cellular signaling pathways.
• Preclinical Studies: Utilized in the formulation of compounds for pharmacological and toxicological evaluation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.

Basic Information

Item	Detail
Product Name	n-[4-[(6,7-Dimethoxy-4-Quinolinyl)Oxy]Phenyl]-N'-(4-Fluoro-3-Hydroxyphenyl)-1,1-Cyclopropanedicarboxamide
CAS No.	1628530-41-5
Molecular Formula	C28H24FN3O6
Molecular Weight	517.51 g/mol
Synonyms	1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluoro-3-hydroxyphenyl)-; UNII-8V4U6A8KQO; 8V4U6A8KQO; BDBM50190057; CHEMBL3186665; AKOS009158974; ZINC000003869007; TAK-285 intermediate
EINECS	Contact for details

Quality Control

Our n-[4-[(6,7-Dimethoxy-4-Quinolinyl)Oxy]Phenyl]-N'-(4-Fluoro-3-Hydroxyphenyl)-1,1-Cyclopropanedicarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with ICH guidelines and supports cGMP-compliant applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.