Description

1-Bromo-4-(Difluoromethyl)-2,5-Difluorobenzene is a high-purity, multi-functional fluorinated aromatic building block. This compound is valued for its unique substitution pattern, which makes it a versatile intermediate in advanced organic synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules with specific fluorine motifs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring difluoromethyl and halogenated aromatic groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved pesticidal activity and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, enabling the construction of complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and developing new fluorination methodologies in academic and industrial R&D settings.
• Ligand and Catalyst Development: Used to synthesize novel fluorinated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Bromo-4-(Difluoromethyl)-2,5-Difluorobenzene
CAS No.	1628442-65-8
Molecular Formula	C7H3BrF4
Molecular Weight	242.99 g/mol
Synonyms	2,5-Difluoro-4-(difluoromethyl)bromobenzene; 4-Bromo-2,5-difluorobenzylidene difluoride; 1-Bromo-4-(difluoromethyl)-2,5-difluorobenzene; 4-(Difluoromethyl)-2,5-difluorobromobenzene; 2,5-Difluoro-α,α-difluoro-4-bromotoluene; Benzene, 1-bromo-4-(difluoromethyl)-2,5-difluoro-; (2,5-Difluoro-4-bromophenyl)difluoromethane
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Difluoromethyl)-2,5-Difluorobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.