Description

Azd 3759 CAS NO 1626387-80-1 is a potent and selective small molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is of significant value in pharmaceutical research and development, particularly for its targeted mechanism of action. It is primarily required by research institutions and pharmaceutical companies engaged in the discovery and preclinical study of novel oncology therapeutics.

Application

• Oncology Research: A key tool compound for studying EGFR-driven tumorigenesis and resistance mechanisms in various cancer cell lines.
• Drug Discovery: Used as a reference standard or lead compound in the development of next-generation EGFR tyrosine kinase inhibitors (TKIs).
• Biochemical Assays: Employed in high-throughput screening (HTS) and enzymatic assays to evaluate EGFR kinase activity and inhibition.
• Preclinical Studies: Utilized in animal models to investigate the pharmacokinetics, efficacy, and safety profiles of EGFR-targeted therapies.
• Mechanism of Action Studies: Critical for research focused on understanding signal transduction pathways and apoptosis in cancer cells.
• Academic Research: Serves as a vital reagent in university and institutional labs for fundamental cancer biology research.

Basic Information

Product Name	Azd 3759
CAS No.	1626387-80-1
Molecular Formula	C₂₄H₂₅ClFN₅O₃
Molecular Weight	485.94 g/mol
Synonyms	AZD-3759; AZD3759; N-[3-[(2-[(2,6-Dichlorophenyl)amino]-5-fluoropyrimidin-4-yl)amino]phenyl]acrylamide; EGFR Inhibitor AZD3759; 2,6-Dichloro-N-[5-fluoro-4-[3-(2-propenoylamino)anilino]pyrimidin-2-yl]benzamide
EINECS	Contact for details

Quality Control

Our Azd 3759 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.