Description

Pf-04965842 (Abrocitinib) is a potent and selective Janus kinase 1 (JAK1) inhibitor, representing a significant advancement in targeted immunomodulatory therapy. This compound is crucial for pharmaceutical research and development, offering a targeted mechanism of action for modulating inflammatory pathways. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutics for autoimmune and inflammatory dermatological conditions.

Application

• Pharmaceutical R&D: Primary active pharmaceutical ingredient (API) in the development of oral treatments for moderate-to-severe atopic dermatitis.
• Preclinical & Clinical Studies: Used in pharmacokinetic, pharmacodynamic, and toxicology studies to establish safety and efficacy profiles.
• Mechanism of Action Research: A critical tool compound for investigating JAK-STAT signaling pathways in immunological diseases.
• Formulation Development: Serves as the key component in the development of solid oral dosage forms such as tablets.
• Reference Standard: Used as a high-purity chemical reference standard for quality control and analytical method development.
• Comparative Bioactivity Studies: Employed in research comparing the efficacy and selectivity profiles of different JAK inhibitors.

Basic Information

Product Name	Pf-04965842 (Abrocitinib)
CAS No.	1622902-68-4
Molecular Formula	C14H21N5O
Molecular Weight	275.35 g/mol
Synonyms	Abrocitinib; PF-04965842; (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide; CIBINQO; PF 04965842; JAK1 Inhibitor PF-04965842; UNII-9038R3Q8J9
EINECS	Contact for details

Quality Control

Our Pf-04965842 (Abrocitinib) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.