Description

Gsk3145095 is a potent and selective small molecule inhibitor of RIP1 kinase, a key regulator of necroptosis and inflammation. This high-purity compound is essential for advanced research in cell death pathways and inflammatory disease models. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for conditions like inflammatory bowel disease, psoriasis, and neurodegenerative disorders.

Application

• Pharmaceutical Research & Development: A critical tool for investigating the role of RIP1 kinase in necroptosis and inflammation, supporting target validation and drug discovery programs.
• Preclinical Disease Modeling: Used in in vitro and in vivo studies to model and understand the pathophysiology of inflammatory and autoimmune diseases.
• Mechanistic Biology Studies: Enables detailed study of cell death signaling pathways (apoptosis vs. necroptosis) and their interplay with the immune response.
• Biomarker Discovery: Assists in identifying and validating biomarkers associated with RIP1 kinase activity and inflammatory conditions.
• High-Throughput Screening (HTS): Serves as a reference standard or positive control in assay development and screening campaigns for RIP1 inhibitors.
• Academic Research: Supports fundamental research in immunology, cell biology, and molecular pharmacology at universities and research institutes.

Basic Information

Product Name	Gsk3145095
CAS No.	1622849-43-7
Molecular Formula	C₂₀H₂₀N₆O₃
Molecular Weight	392.41 g/mol
Synonyms	7-Oxo-2,4,7,8-tetrahydro-1H-cyclopenta[4,5]pyrrolo[2,3-b]pyridine-6-carbonitrile, 3-(4-((4-(Dimethylamino)piperidin-1-yl)methyl)phenyl)-1-methyl-; GSK'095; GSK-3145095; GSK3145095; RIP1 Inhibitor; Receptor-interacting serine/threonine-protein kinase 1 Inhibitor
EINECS	Contact for details

Quality Control

Our Gsk3145095 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.