Description

2-Bromo-1-(3,3-Difluorocyclobutyl)Ethan-1-One is a high-value, specialized organic building block featuring a reactive bromoacetyl group attached to a difluorinated cyclobutyl ring. This unique molecular architecture makes it a critical intermediate for medicinal chemistry and advanced material science, enabling the synthesis of novel compounds with tailored properties. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluorocyclobutyl moiety can enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Precursor: Employed in the research of advanced polymers and liquid crystals, where the incorporation of fluorine can modify physical properties like thermal stability and solubility.
• Chemical Biology Probe Synthesis: Useful for creating molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	2-Bromo-1-(3,3-Difluorocyclobutyl)Ethan-1-One
CAS No.	1619911-80-6
Molecular Formula	C6H7BrF2O
Molecular Weight	213.02 g/mol
Synonyms	2-Bromo-1-(3,3-difluorocyclobutyl)ethanone; 2-Bromo-1-(3,3-difluorocyclobutyl)ethan-1-one; 1-(3,3-Difluorocyclobutyl)-2-bromoethanone; α-Bromo-3,3-difluorocyclobutan-1-yl methyl ketone; 2-Bromo-3',3'-difluorocyclobutan-1-yl methyl ketone; Bromo(3,3-difluorocyclobutyl)methanone
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-1-(3,3-Difluorocyclobutyl)Ethan-1-One adheres to stringent quality management protocols. Each batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.