Description

Tic10 CAS NO 1616632-77-9 is a potent and selective small molecule inhibitor of the Akt signaling pathway, a critical regulator of cell survival, growth, and proliferation. This compound matters as a valuable research tool for investigating oncogenic pathways and exploring potential therapeutic strategies in cancer biology. It is primarily needed by researchers and scientists in the fields of oncology, molecular biology, and pharmaceutical development for in vitro and in vivo studies.

Application

• Biomedical Research: Used as a key pharmacological agent to study the role of Akt signaling in various cellular processes and disease models.
• Oncology Studies: Employed in cancer research to investigate tumor cell survival, proliferation, and sensitivity to apoptosis.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the screening and development of novel anti-cancer therapeutics.
• Signal Transduction Analysis: A tool for dissecting complex signaling networks downstream of growth factor receptors and PI3K.
• Academic & Institutional Research: Utilized in university and research institute laboratories for fundamental biological studies.
• Preclinical Testing: Applied in animal models to evaluate the efficacy and mechanism of action of pathway inhibition.

Basic Information

Product Name	Tic10
CAS No.	1616632-77-9
Molecular Formula	C₁₉H₁₈N₄O₂
Molecular Weight	334.37 g/mol
Synonyms	ONC201; NSC-350625; TIC10; 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[(2-methyl-5-pyridinyl)methyl]pyrido[4,3-b]indol-1(2H)-one; TRAIL-Inducing Compound 10
EINECS	Contact for details

Quality Control

Our Tic10 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.