Description

Tucidinostat (Chidamide) CAS NO 1616493-44-7 is a potent and selective histone deacetylase (HDAC) inhibitor, specifically targeting HDAC subtypes 1, 2, 3, and 10. This mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of novel epigenetic therapies. It is primarily required by pharmaceutical manufacturers and research institutions engaged in oncology drug development and clinical trials for hematologic and solid tumors.

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of finished dosage forms, primarily oral tablets.
• Key component in clinical research and development of novel cancer therapeutics targeting epigenetic pathways.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical research tool for studying HDAC inhibition, chromatin remodeling, and gene expression regulation.
• Preclinical studies investigating combination therapies with other anti-cancer agents.
• Production of generic oncology medications following patent expiry in applicable markets.

Basic Information

Product Name	Tucidinostat (Chidamide)
CAS No.	1616493-44-7
Molecular Formula	C22H19FN4O2
Molecular Weight	390.41 g/mol
Synonyms	Chidamide; HBI-8000; CS-055; N-(2-Amino-4-fluorophenyl)-4-[[N-[(E)-3-(3-pyridinyl)acryloyl]amino]methyl]benzamide; Epidaza; Tucidinostat; HDAC Inhibitor HBI-8000; CS055; Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(1E)-3-(3-pyridinyl)-1-propen-1-yl]amino]methyl]-
EINECS	Contact for details

Quality Control

Our Tucidinostat (Chidamide) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.