Description

5-(n-Isopentenyl-n-Trifluoroacetyl) Aminomethyluridine is a specialized, high-purity nucleoside derivative designed for advanced research and pharmaceutical development. This compound is a critical building block in the synthesis of modified oligonucleotides, enabling the study of RNA structure, function, and therapeutic potential. It is primarily utilized by research institutions and biotechnology companies focused on nucleic acid chemistry, antisense technology, and the development of novel mRNA-based therapeutics and diagnostics.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the site-specific incorporation of modified uridine into synthetic RNA strands.
• RNA Research: Used to study RNA structure, stability, and protein-RNA interactions by introducing specific functional groups.
• Therapeutic Development: Serves as a critical intermediate in the development of mRNA vaccines, antisense oligonucleotides, and siRNA therapeutics.
• Diagnostic Probe Design: Enables the creation of labeled or modified nucleic acid probes for advanced diagnostic assays and detection systems.
• Bioconjugation: The reactive handles facilitate conjugation with reporter molecules, delivery agents, or other biomolecules.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of nucleic acid-based drugs.

Basic Information

Product Name	5-(n-Isopentenyl-n-Trifluoroacetyl) Aminomethyluridine
CAS No.	1613530-43-0
Molecular Formula	C17H22F3N3O7
Molecular Weight	437.37 g/mol
Synonyms	5-[(3-Methylbut-2-en-1-yl)(2,2,2-trifluoroacetyl)amino]methyluridine; 5-[(N-Isopentenyl-N-trifluoroacetyl)aminomethyl]uridine; 5-(N-Isopentenyl-N-TFA)aminomethyluridine; 5-Isopentenylaminomethyluridine TFA derivative; Modified Uridine Derivative; TFA-protected Aminomethyluridine; RNA Building Block 1613530-43-0
EINECS	Contact for details

Quality Control

Every batch of 5-(n-Isopentenyl-n-Trifluoroacetyl) Aminomethyluridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by 1H/13C NMR and MS), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.