Description

5-Pyrrolidinomethyluridine is a chemically modified nucleoside analog, specifically a uridine derivative with a pyrrolidinomethyl substituent at the 5-position. This structural modification is crucial for enhancing its utility as a key building block and intermediate in advanced pharmaceutical and biochemical research. It is primarily sought after by research institutions and manufacturers in the fields of oligonucleotide synthesis, prodrug development, and medicinal chemistry for creating novel therapeutic agents.

Application

• Oligonucleotide Synthesis: Serves as a modified monomer for the solid-phase synthesis of therapeutic and diagnostic oligonucleotides, including antisense, siRNA, and aptamers.
• Pharmaceutical Intermediates: Acts as a critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate RNA metabolism and related biological pathways.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new chemical entities with improved pharmacokinetic properties.
• Labeled Compound Synthesis: A starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing and imaging studies.

Basic Information

Product Name	5-Pyrrolidinomethyluridine
CAS No.	1613530-41-8
Molecular Formula	C14H19N3O6
Molecular Weight	325.32 g/mol
Synonyms	5-[(Pyrrolidin-1-yl)methyl]uridine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(pyrrolidin-1-ylmethyl)pyrimidine-2,4-dione; Uridine, 5-[(1-pyrrolidinyl)methyl]-; 5-Pyrrolidin-1-ylmethyluridine; 5-(N-Pyrrolidinomethyl)uridine
EINECS	Contact for details

Quality Control

Our 5-Pyrrolidinomethyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with customer specifications for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.