Description

Cytidine, 3',5'-Bis-o-[(1,1-Dimethylethyl)Dimethylsilyl]-n-Methyl-2'-o-Methyl- CAS NO 1613530-40-7 is a highly modified nucleoside derivative, specifically engineered with protective silyl and methyl groups to enhance its stability and reactivity for advanced synthetic applications. This compound is a critical building block in the synthesis of complex oligonucleotides and nucleotide analogs, where precise chemical modification is paramount. It is primarily needed by research institutions and pharmaceutical companies engaged in antisense drug development, RNA therapeutics, and the creation of novel diagnostic probes.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense & siRNA Therapeutics: Used to create nucleoside monomers with enhanced nuclease resistance and binding affinity for therapeutic oligonucleotides.
• Chemical Biology Research: Serves as a vital tool for studying RNA structure, function, and metabolism through site-specific incorporation.
• Diagnostic Probe Development: Employed in the manufacture of labeled nucleotides for fluorescence in situ hybridization (FISH) and other detection assays.
• Pharmaceutical Intermediate: Acts as a sophisticated intermediate in the multi-step synthesis of novel antiviral and anticancer nucleoside drugs.
• Academic & Industrial R&D: Fundamental for exploring new nucleotide chemistries and developing next-generation genetic medicines.

Basic Information

Product Name	Cytidine, 3',5'-Bis-o-[(1,1-Dimethylethyl)Dimethylsilyl]-n-Methyl-2'-o-Methyl-
CAS No.	1613530-40-7
Molecular Formula	C22H43N3O5Si2
Molecular Weight	485.77 g/mol
Synonyms	3',5'-Bis-O-(tert-butyldimethylsilyl)-N-methyl-2'-O-methylcytidine; 2'-O-Methyl-3',5'-bis-O-(tert-butyldimethylsilyl)-N-methylcytidine; N-Methyl-2'-O-methyl-3',5'-bis-O-(TBDMS)cytidine; 2'-O-Me-3',5'-bis-TBDMS-N-Me-cytidine; Protected N-Methyl-2'-O-methylcytidine; TBDMS-protected cytidine derivative; Cytidine derivative CAS 1613530-40-7
EINECS	Contact for details

Quality Control

Our production of this advanced nucleoside intermediate adheres to stringent quality assurance protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and high chemical purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.