Description

N1-Cyclopropylmethylpseudouridine is a chemically modified nucleoside analog, specifically engineered for advanced pharmaceutical and biotechnology research. This high-purity compound is critical for enhancing the stability and efficacy of mRNA-based therapeutics and vaccines. It is primarily utilized by research institutions, pharmaceutical developers, and CDMOs engaged in the synthesis of next-generation oligonucleotides and modified RNA constructs.

Application

• mRNA Therapeutic & Vaccine Development: As a key raw material for incorporating modified nucleosides to improve mRNA stability, reduce immunogenicity, and enhance translational efficiency.
• Oligonucleotide Synthesis: Used in the solid-phase synthesis of research-grade and therapeutic oligonucleotides for antisense, siRNA, and aptamer applications.
• Biochemical Research: Serves as a critical reagent in studies investigating RNA structure, function, and metabolism.
• Process Development & Scale-up: Employed by contract development and manufacturing organizations (CDMOs) for process optimization and GMP-grade production of modified nucleosides.
• Reference Standard: Used as an analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.

Basic Information

Product Name	N1-Cyclopropylmethylpseudouridine
CAS No.	1613530-18-9
Molecular Formula	C13H17N3O6
Molecular Weight	311.29 g/mol
Synonyms	1-Cyclopropylmethylpseudouridine; N1-Cyclopropylmethyl-ψ-uridine; ψ-Cyclopropylmethyluridine; Pseudouridine, N1-(cyclopropylmethyl)-; 5-[(Cyclopropylmethyl)amino]-1-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione; CPMPU; Modified Nucleoside CPMPU; 1-(Cyclopropylmethyl)pseudouridine
EINECS	Contact for details

Quality Control

Our N1-Cyclopropylmethylpseudouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.