Description

N1-Allylpseudouridine is a chemically modified nucleoside analog, specifically an allyl-substituted derivative of pseudouridine. This compound is of significant value in the field of nucleic acid chemistry and biotechnology, serving as a critical building block for the synthesis of modified RNA. It is primarily needed by research institutions, pharmaceutical developers, and CROs/CDMOs engaged in mRNA therapeutics, vaccine development, and fundamental biochemical research to enhance stability and reduce immunogenicity.

Application

• mRNA Therapeutic & Vaccine Development: As a key raw material for incorporating modified nucleosides into mRNA sequences to improve translational efficiency and stability.
• Biochemical Research: Used in studies investigating RNA structure, function, and the impact of specific modifications on biological activity.
• Oligonucleotide Synthesis: Serves as a phosphoramidite precursor for the solid-phase synthesis of research-grade and therapeutic oligonucleotides.
• Antiviral Drug Discovery: Investigated as a potential scaffold or intermediate in the development of nucleoside analog-based antiviral agents.
• Diagnostic Probe Development: Utilized in the creation of labeled probes for detecting specific RNA sequences.

Basic Information

Product Name	N1-Allylpseudouridine
CAS No.	1613530-15-6
Molecular Formula	C12H16N2O6
Molecular Weight	284.27 g/mol
Synonyms	1-Allyl-5-ribosyluracil; 1-Allylpseudouridine; 5-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-prop-2-enylpyrimidine-2,4-dione; N1-Allyl-5-β-D-ribofuranosyluracil; Allyl-ψ; Pseudouridine, 1-allyl-; N1-Allyl-ψ
EINECS	Contact for details

Quality Control

Our N1-Allylpseudouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.