Description

6-Methylpseudouridine is a chemically modified nucleoside analog of uridine, where a methyl group is introduced at the 6-position of the pseudouridine base. This modification is critical for enhancing the stability and translational efficiency of mRNA, making it a key component in advanced therapeutic and vaccine development. It is an essential raw material for pharmaceutical R&D and manufacturing, particularly for companies specializing in mRNA-based technologies, oligonucleotide synthesis, and life science research.

Application

• mRNA Vaccine & Therapeutic Manufacturing: A critical building block for synthesizing modified mRNA to improve protein expression and reduce immunogenicity.
• Oligonucleotide Synthesis: Used in the production of modified antisense oligonucleotides (ASOs), siRNA, and other RNA-based therapeutics.
• Biochemical Research: A vital tool for studying RNA structure, function, and metabolism in academic and industrial research laboratories.
• Pharmaceutical Intermediates: Serves as a high-purity intermediate for the synthesis of more complex nucleoside-based active pharmaceutical ingredients (APIs).
• Diagnostic Probe Development: Employed in the design of labeled probes for nucleic acid detection and diagnostic assays.

Basic Information

Product Name	6-Methylpseudouridine
CAS No.	1613530-10-1
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	N1-Methylpseudouridine; 1-Methyl-5-ribosyluracil; 6-Methyl-β-pseudouridine; m1ψ; 1-Methylpseudouridine; 5-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-methylpyrimidine-2,4(1H,3H)-dione; 1-Methyl-5-(β-D-ribofuranosyl)uracil
EINECS	Contact for details

Quality Control

Our 6-Methylpseudouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications developed for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.