Description

N1-(1,1,1-Trifluoroethyl)Pseudouridine is a chemically modified nucleoside analog, specifically a trifluoroethylated derivative of pseudouridine, designed to enhance stability and modulate biological activity. This modification is critical for applications requiring improved metabolic resistance and altered binding affinity compared to its parent compound. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of advanced therapeutics such as mRNA vaccines, oligonucleotide-based drugs, and novel antiviral agents.

Application

• mRNA Vaccine & Therapeutic Development: As a critical modified nucleoside for enhancing mRNA stability and reducing immunogenicity.
• Antiviral Drug Research: Serves as a building block in the synthesis of nucleoside analogs targeting viral polymerases.
• Oligonucleotide Synthesis: Used in the production of modified siRNA, antisense oligonucleotides, and aptamers for research and therapeutic purposes.
• Biochemical Research: A tool compound for studying RNA structure, function, and processing mechanisms.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate in the production of more complex active pharmaceutical ingredients (APIs).
• Diagnostic Probe Development: Employed in the creation of labeled probes for nucleic acid detection and sequencing technologies.

Basic Information

Product Name	N1-(1,1,1-Trifluoroethyl)Pseudouridine
CAS No.	1613529-80-8
Molecular Formula	C11H14F3N2O6
Molecular Weight	327.24 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)pseudouridine; 5-[(2,2,2-Trifluoroethyl)amino]-1-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione; N1-Trifluoroethyl-ψ; Trifluoroethyl Pseudouridine; 1-Trifluoroethylpseudouridine; ψ(CF3CH2); Modified Nucleoside 1613529-80-8; N1-(2,2,2-Trifluoroethyl)-5-ribosyluracil
EINECS	Contact for details

Quality Control

Our N1-(1,1,1-Trifluoroethyl)Pseudouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.