Description

Rpt-835 (Alofanib) is a potent and selective small molecule inhibitor targeting fibroblast growth factor receptor (FGFR) tyrosine kinases. This compound is of significant interest for its potential in oncology research and therapeutic development, particularly in targeting cancers driven by FGFR signaling dysregulation. It is a critical research chemical for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies engaged in cancer biology, kinase inhibitor discovery, and preclinical drug development.

Application

• Oncology Research: Primary tool compound for studying FGFR signaling pathways and their role in tumorigenesis, proliferation, and metastasis.
• Drug Discovery & Development: Used as a reference standard or lead compound in the screening and optimization of novel FGFR-targeted therapeutic agents.
• Biochemical Assays: Employed in in vitro kinase inhibition assays to determine potency, selectivity, and mechanism of action against FGFR family members.
• Preclinical Studies: Utilized in cell-based models and animal studies to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of FGFR inhibition.
• Chemical Biology: Serves as a molecular probe to investigate the biological functions and downstream effects of FGFRs in various disease contexts.

Basic Information

Product Name	Rpt-835 (Alofanib)
CAS No.	1612888-66-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Alofanib; RPT-835; RPT 835; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2-[[3-[(4-cyanophenyl)amino]-1H-pyrrolo[2,3-b]pyridin-2-yl]thio]-N-[4-(methylsulfonyl)phenyl]acetamide; FGFR inhibitor RPT-835
EINECS	Contact for details

Quality Control

Our Rpt-835 (Alofanib) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C. The compound is light-sensitive; handling should be performed under appropriate light conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.