Description

Cytidine, 2'-Deoxy-2',2'-Difluoro-n-(2-Methyl-1-Oxopropyl)- is a high-purity, modified nucleoside derivative of significant interest in advanced pharmaceutical research and development. This compound, with CAS number 1571909-13-1, serves as a critical intermediate in the synthesis of novel therapeutic agents, particularly in the field of oncology. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and fine chemical manufacturers engaged in the production of nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog drugs, especially anticancer and antiviral agents.
• Anticancer Drug Development: Used in the research and production of chemotherapeutic compounds, including prodrugs and targeted therapies.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Antiviral Agent Synthesis: Serves as a precursor in the development of nucleoside reverse transcriptase inhibitors and other antiviral compounds.
• Prodrug Synthesis: Utilized to create prodrug forms of active pharmaceutical ingredients to enhance bioavailability and targeting.
• Fine Chemical Manufacturing: A specialized intermediate for custom synthesis and contract manufacturing organizations (CMOs) serving the pharma sector.

Basic Information

Product Name	Cytidine, 2'-Deoxy-2',2'-Difluoro-n-(2-Methyl-1-Oxopropyl)-
CAS No.	1571909-13-1
Molecular Formula	C17H23F2N3O6
Molecular Weight	403.38 g/mol
Synonyms	2'-Deoxy-2',2'-difluoro-N-(2-methyl-1-oxopropyl)cytidine; 2'-Deoxy-2',2'-difluoro-N-isobutyrylcytidine; Gemcitabine N4-isobutyryl intermediate; 4-N-Isobutyryl-2'-deoxy-2',2'-difluorocytidine; 1-(2-Deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)-4-(isobutyrylamino)-2(1H)-pyrimidinone; Cytidine, 2'-deoxy-2',2'-difluoro-, 4-(2-methylpropanoate); Gemcitabine N4-isobutyrate; DFDC-N4-Ibu
EINECS	Contact for details

Quality Control

Our Cytidine, 2'-Deoxy-2',2'-Difluoro-n-(2-Methyl-1-Oxopropyl)- is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, suitable for pharmaceutical R&D applications. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Maximum Impurity	≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.