Description

2''-Deoxy-3''-o-[(1,1-Dimethylethyl)Dimethylsilyl]-N,5-Dimethyl-Cytidine is a key protected nucleoside derivative, specifically engineered for advanced oligonucleotide synthesis and pharmaceutical research. This compound is critical for researchers and manufacturers requiring high-purity, chemically modified building blocks to develop novel therapeutics, including antisense oligonucleotides and siRNA. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, biotechnology, and fine chemical sectors focused on next-generation nucleic acid-based drugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial protected monomer in the solid-phase synthesis of modified oligonucleotides for therapeutic applications.
• Antisense Oligonucleotide (ASO) Development: Used to incorporate specific modifications that enhance drug stability, target affinity, and pharmacokinetic properties.
• siRNA and RNAi Therapeutic Research: Acts as a building block for synthesizing chemically stabilized siRNA strands to improve nuclease resistance and efficacy.
• Medicinal Chemistry & Drug Discovery: Employed in structure-activity relationship (SAR) studies to explore novel nucleoside analogs with potential biological activity.
• Process Development & Scale-up: Supports the transition from laboratory-scale research to GMP-compliant commercial manufacturing of active pharmaceutical ingredients (APIs).
• Bioconjugation and Probe Synthesis: Facilitates the creation of labeled nucleosides for diagnostic assays and biochemical research tools.

Basic Information

Product Name	2''-Deoxy-3''-o-[(1,1-Dimethylethyl)Dimethylsilyl]-N,5-Dimethyl-Cytidine
CAS No.	1569273-35-3
Molecular Formula	C18H33N3O4Si
Molecular Weight	383.56 g/mol
Synonyms	3'-O-TBDMS-N,5-Dimethyl-2'-deoxycytidine; N,5-Dimethyl-2'-deoxycytidine 3'-(tert-butyldimethylsilyl) ether; 2'-Deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N,5-dimethylcytidine; TBDMS-N,5-Dimethyl-dC; Protected N,5-Dimethyl-2'-deoxycytidine; N,5-Dimethyl-dC(TBDMS); 3'-O-(tert-Butyldimethylsilyl)-N,5-dimethyl-2'-deoxycytidine
EINECS	Contact for details

Quality Control

Our 2''-Deoxy-3''-o-[(1,1-Dimethylethyl)Dimethylsilyl]-N,5-Dimethyl-Cytidine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We support compliance with cGMP guidelines for advanced intermediates and can provide material for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.