Description

Pseudouridimycin (Pum) is a novel, naturally occurring nucleoside-analog antibiotic that functions as a selective inhibitor of bacterial RNA polymerase. This compound represents a significant advancement in the fight against antimicrobial resistance, offering a distinct mechanism of action from existing drug classes. It is primarily of interest to pharmaceutical R&D teams, biotechnology companies, and academic researchers focused on developing new antibacterial agents to combat multidrug-resistant bacterial infections.

Application

• Antibacterial Drug Discovery & Development: Serves as a lead compound or reference standard in research programs targeting novel antibiotics.
• Mechanistic & Biochemical Research: Used in studies to investigate bacterial transcription inhibition and the structure-activity relationships of RNA polymerase inhibitors.
• Microbiology & Pharmacology: Employed in in vitro and in vivo assays to evaluate potency against a spectrum of Gram-positive and Gram-negative pathogens.
• Pharmaceutical Reference Standard: Utilized as a high-purity analytical standard for quality control, method development, and regulatory submissions.
• Synthetic Chemistry Intermediate: Acts as a key building block for the synthesis of novel analogs to explore and optimize antibacterial activity.

Basic Information

Product Name	Pseudouridimycin (Pum)
CAS No.	1566586-52-4
Molecular Formula	C₂₀H₂₈N₆O₁₁
Molecular Weight	528.47 g/mol
Synonyms	PUM; Pseudouridimycin; 5'-O-[N-(Pseudouridylyl)-sulfamoyl]adenosine; Antibiotic M4-1; RNA Polymerase Inhibitor M4-1; 5'-O-[(Pseudouridine-5'-yl)sulfamoyl]adenosine; Adenosine, 5'-[N-(5-O-phosphono-β-D-ribofuranosyl)-N-sulfonylpseudouridin-5-yl]amino]-5'-deoxy-
EINECS	Contact for details

Quality Control

Our Pseudouridimycin is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.