Description

n-(3-((2-((3-Fluoro-4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Oxy)Phenyl)Acrylamide Maleate is a high-purity, small molecule pharmaceutical intermediate and research chemical. This compound is of significant interest for its role as a key building block in the development of targeted kinase inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced kinase inhibitor candidates for oncology research.
• Biochemical Research: Used as a reference standard or active compound in enzymatic and cellular assays to study signal transduction pathways.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry optimization programs aimed at improving potency and selectivity.
• Preclinical Studies: Employed in in vitro and in vivo studies to evaluate pharmacokinetic and pharmacodynamic properties of drug leads.
• Academic Research: Utilized in university and institutional labs for fundamental research into cancer biology and targeted therapies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale synthesis of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-(3-((2-((3-Fluoro-4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Oxy)Phenyl)Acrylamide Maleate
CAS No.	1557268-88-8
Molecular Formula	C27H28FN7O4 • C4H4O4
Molecular Weight	Contact for details
Synonyms	1557268-88-8
N-[3-({2-[(3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]-2-propenamide maleate
Acrylamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-, (2Z)-2-butenedioate (1:1)
UNII-7J7I4P4H2P
TAK-285 Intermediate Maleate
ASP-3026 Intermediate Maleate
Kinase Inhibitor Intermediate Maleate
EINECS	Contact for details

Quality Control

Our n-(3-((2-((3-Fluoro-4-(4-Methylpiperazin-1-Yl)Phenyl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Oxy)Phenyl)Acrylamide Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) upon request, supporting your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.