Description

2-(3,4-Difluorophenyl)-1-(2-Fluorophenyl)Ethanone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its specific fluorine substitution pattern can modulate biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce unique fluorinated motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides with enhanced efficacy and environmental profile.
• Material Science Research: Serves as a precursor for fluorinated liquid crystals, polymers, or organic electronic materials.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological mechanisms and diagnostics.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: Fundamental research reagent for methodological studies in fluorination chemistry and cross-coupling reactions.

Basic Information

Product Name	2-(3,4-Difluorophenyl)-1-(2-Fluorophenyl)Ethanone
CAS No.	1519952-50-1
Molecular Formula	C14H9F3O
Molecular Weight	250.22 g/mol
Synonyms	1-(2-Fluorophenyl)-2-(3,4-difluorophenyl)ethanone; 2',3,4'-Trifluorochalcone; 2-(3,4-Difluorophenyl)-2-fluoroacetophenone; (2-Fluorophenyl)[(3,4-difluorophenyl)methyl]methanone; α-(3,4-Difluorophenyl)-2-fluoroacetophenone; 2-Fluoro-α-(3,4-difluorophenyl)acetophenone; 1519952-50-1
EINECS	Contact for details

Quality Control

Our 2-(3,4-Difluorophenyl)-1-(2-Fluorophenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.