Description

Afabicin CAS NO 1518800-35-5 is a novel, investigational antibiotic belonging to the pleuromutilin class, specifically designed to target Gram-positive bacteria. Its core value proposition lies in its unique mechanism of action, which inhibits bacterial protein synthesis and shows promising activity against drug-resistant strains, including methicillin-resistant *Staphylococcus aureus* (MRSA). This compound is primarily needed by pharmaceutical research and development organizations, biotechnology companies, and academic institutions engaged in the discovery and development of next-generation anti-infective therapies.

Application

• Pharmaceutical R&D for novel antibiotic discovery programs.
• Preclinical and clinical studies targeting Gram-positive bacterial infections.
• Development of treatments for acute bacterial skin and skin structure infections (ABSSSI).
• Research into therapies for community-acquired bacterial pneumonia (CABP).
• Investigation of agents against methicillin-resistant Staphylococcus aureus (MRSA).
• Mechanistic studies on bacterial protein synthesis inhibition.
• Production of reference standards for analytical and bioanalytical method development.
• Use as a key intermediate in specialized synthetic chemistry for related antimicrobial compounds.

Basic Information

Product Name	Afabicin
CAS No.	1518800-35-5
Molecular Formula	C32H45NO5S
Molecular Weight	555.77 g/mol
Synonyms	AFN-1252; (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-5,6,8,9,9a,10-hexahydro-3aH-cyclopenta[b]naphtho[2,1-d]furan-8-yl 4-{[(3S)-3-(methylsulfanyl)-1-oxobutan-2-yl]amino}benzoate; Debio 1452; Debio-1452; Pleuromutilin derivative AFN-1252; LEK-001; LEK001
EINECS	Contact for details

Quality Control

Our Afabicin is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and related substances is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (HPLC)	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.